Scientists Find Brain Region That Helps You Make Up Your Mind

14.2k Engagements 19 Shares

Stan Floresco and Colin Stopper. Image: University of British Columbia

Stan Floresco and Colin Stopper. Image: University of British Columbia

View Comments

Vancouver, BC Canada (Scicasts) – One of the smallest parts of the brain is getting a second look after new research suggests it plays a crucial role in decision making.

A University of British Columbia study published Nov. 24 in Nature Neuroscience says the lateral habenula, a region of the brain linked to depression and avoidance behaviours, has been largely misunderstood and may be integral in cost-benefit decisions.

“These findings clarify the brain processes involved in the important decisions that we make on a daily basis, from choosing between job offers to deciding which house or car to buy,” says Prof. Stan Floresco of UBC’s Dept. of Psychology and Brain Research Centre (BRC). “It also suggests that the scientific community has misunderstood the true functioning of this mysterious, but important, region of the brain.”

In the study, scientists trained lab rats to choose between a consistent small reward (one food pellet) or a potentially larger reward (four food pellets) that appeared sporadically. Like humans, the rats tended to choose larger rewards when costs—in this case, the amount of time they had to wait before receiving food–were low and preferred smaller rewards when such risks were higher.

Previous studies suggest that turning off the lateral habenula would cause rats to choose the larger, riskier reward more often, but that was not the case. Instead, the rats selected either option at random, no longer showing the ability to choose the best option for them.

The findings have important implications for depression treatment. “Deep brain stimulation – which is thought to inactivate the lateral habenula — has been reported to improve depressive symptoms in humans,” Floresco says. “But our findings suggest these improvements may not be because patients feel happier. They may simply no longer care as much about what is making them feel depressed.”


Floresco, who conducted the study with PhD candidate Colin Stopper, says more investigation is needed to understand the complete brain functions involved in cost-benefit decision processes and related behaviour. A greater understanding of decision-making processes is also crucial, they say, because many psychiatric disorders, such as schizophrenia, stimulant abuse and depression, are associated with impairments in these processes.

The lateral habenula is considered one of the oldest regions of the brain, evolution-wise, the researchers say.

Publication: What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases. Colin M Stopper, Stan B Floresco.  Nature Neuroscience (2013):


comments powered by Disqus
More from Neuroscience Channel

  Sector's Activity Matrix

3 Months Ending Jul/27/2014
Latest Developments

Schizophrenia's Genetic 'Skyline' Rising

Bethesda, MD (Scicasts) — The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harbouring inherited variations in the genetic code linked to...

786 Engagements 5 Shares

Diagnostic Criteria for Christianson Syndrome

Providence, RI (Scicasts) — Because the severe autism-like condition Christianson Syndrome was only first reported in 1999 and some symptoms take more than a decade to appear, families and doctors...

636 Engagements 4 Shares