Iowa City, IA (Scicasts) — A recent scientific discovery showed that mutations in prickle genes cause epilepsy, which in humans is a brain disorder characterized by repeated seizures over time. However, the mechanism responsible for generating prickle-associated seizures was unknown.
London, UK (Scicasts) — Researchers at the BBSRC-funded Babraham Institute, in collaboration with the Wellcome Trust Sanger Institute Single Cell Genomics Centre, have developed a powerful new single-cell technique to help investigate how the environment affects our development and the traits we inherit from our parents.
La Jolla, CA (Scicasts) — Scientists at the Salk Institute have identified a gene responsible for stopping the movement of cancer from the lungs to other parts of the body, indicating a new way to fight one of the world’s deadliest cancers. [Video]
Manhattan, KS (Scicasts) — Several Kansas State University researchers were essential in helping scientists assemble a draft of a genetic blueprint of bread wheat, also known as common wheat. The food plant is grown on more than 531 million acres around the world and produces nearly 700 million tons of food each year.
Houston, TX (Scicasts) — Rice University scientists have succeeded in analyzing transmembrane protein folding in the same way they study the proteins’ free-floating, globular cousins. [Video]
Munich, Germany (Scicasts) — Many animals exhibit segmental patterns that manifest themselves during development. One classical example is the sequential and rhythmic formation the segmental precursors of the backbone, a process that has been linked to the ticking of an oscillator in the embryo – the "segmentation clock".
Madrid, Spain (Scicasts) — The Spanish National Cancer Research Centre (CNIO) Macromolecular Crystallography Group has managed to reprogramme the binding of a protein called BuD to DNA in order to redirect it towards specific DNA regions.
Los Angeles, CA (Scicasts) — For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.
Hinxton, UK (Scicasts) — Academic and industry researchers worldwide will be able to carry out research and development into human disease more rapidly due to a non-exclusive partnership between European Conditional Mouse Mutational Program (EUCOMM) members Wellcome Trust Sanger Institute and Helmholtz Zentrum München, and genOway, a specialist producer and distributer of modified mouse resources.
New York, NY (Scicasts) — By switching off a single gene, scientists at Columbia University’s Naomi Berrie Diabetes Center have converted human gastrointestinal cells into insulin-producing cells, demonstrating in principle that a drug could retrain cells inside a person’s GI tract to produce insulin.
Princeton, NJ (Scicasts) — A study led by Princeton University researchers has revealed that the gene Metadherin — which is implicated in promoting the spread of breast cancer tumours — only stimulates tumour growth when the protein made by the gene interacts with a second protein known as SND1.
Menlo Park, CA (Scicasts) — The molecular building blocks that make up DNA absorb ultraviolet light so strongly that sunlight should deactivate them – yet it does not. Now scientists have made detailed observations of a “relaxation response” that protects these molecules, and the genetic information they encode, from UV damage.
Philadelphia, PA (Scicasts) — A team led by researchers from the Perelman School of Medicine at the University of Pennsylvania found that a susceptibility gene for type 1 diabetes regulates self-destruction of the cell’s energy factory. They report their findings this week in Cell.
Philadelphia, PA (Scicasts) — When a woman experiences a stressful event early in pregnancy, the risk of her child developing autism spectrum disorders or schizophrenia increases. Yet how maternal stress is transmitted to the brain of the developing foetus, leading to these problems in neurodevelopment, is poorly understood.
Boston, MA (Scicasts) — Autistic-like behaviours and decreased cognitive ability may be associated with disruption of the function of the Adenomatous Polyposis Coli (APC) gene.
Stanford, CA (Scicasts) — The first large-scale, comprehensive analysis of the genomic diversity of Mexico — led by researchers at the Stanford University School of Medicine, the University of California-San Francisco and the Mexican National Institute of Genomic Medicine — has identified a dazzling mosaic of genotypes and population substructures across the country.
Bethesda, MD (Scicasts) — Most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches, researchers funded by the National Institutes of Health have found. Heritability also outweighed other risk factors in this largest study of its kind to date.
Manhattan, KS (Scicasts) — Ultrafast X-ray laser research led by Kansas State University has provided scientists with a snapshot of a fundamental molecular phenomenon. The finding sheds new light on microscopic electron motion in molecules.
New York, NY (Scicasts) — Evidence from human famines and animal studies suggests that starvation can affect the health of descendants of famished individuals. But how such an acquired trait might be transmitted from one generation to the next has not been clear.
Oak Ridge, TN (Scicasts) — Neutron scattering research at the Department of Energy's Oak Ridge National Laboratory has revealed clear structural differences in the normal and pathological forms of a protein involved in Huntington's disease.
New York, NY (Scicasts) — Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss.
Leicester, UK (Scicasts) — An international team of researchers, led by the University of Leicester, has solved a long-standing mystery in biology, by identifying the molecular structure of a vital biological chemical. The debate – which has raged within the scientific community for years – boils down to something as simple as a hydrogen atom: is it there, or is it not?
New York, NY (Scicasts) — Key genetic variants may affect how cancer patients respond to radiation treatments, according to a study published this week in Nature Genetics.
Mainz, Germany (Scicasts) — Physicists of Johannes Gutenberg University Mainz (JGU) and the Graduate School of Excellence "Materials Science in Mainz" (MAINZ) have been able with the aid of computer simulations to confirm and explain a mechanism by which two knots on a DNA strand can interchange their positions.
Hinxton, UK (Scicasts) — Researchers have exploited a natural experiment created by our use of insecticides to show that large regions of DNA can move between the two types of mosquito that are most important in spread of malaria.
Santa Barbara, CA (Scicasts) — The functional organization of the central nervous system depends upon a precise architecture and connectivity of distinct types of neurons. Multiple cell types are present within any brain structure, but the rules governing their positioning, and the molecular mechanisms mediating those rules, have been relatively unexplored.
Oxford, UK (Scicasts) — Computer analysis of photographs could help doctors diagnose which condition a child with a rare genetic disorder has, say Oxford University researchers.
Salt Lake City, UT (Scicasts) — Only 15% of patients with squamous cell lung cancer – the second most common lung cancer – survive five years past diagnosis. Little is understood about how the deadly disease arises, preventing development of targeted therapies that could serve as a second line of defence once standard chemotherapy regimens fail.
Copenhagen, Denmark (Scicasts) — New Danish genetics research explains the high incidence of type 2 diabetes in the Greenlandic population. The findings have just been published in the scientific journal Nature.
Hinxton, UK (Scicasts) — Researchers have deduced essential biological and genetic information from the genome sequence of the whipworm, an intestinal parasitic worm that infects hundreds of millions of people in developing countries. This information acts as the foundation for the development of new strategies and treatments against this debilitating parasite.