Philadelphia, PA (Scicasts) — Over the last few decades researchers have characterized a set of clock genes that drive daily rhythms of physiology and behaviour in all types of species, from flies to humans.
Columbus, OH (Scicasts) — It’s long been known that certain strains of human papillomavirus (HPV) cause cancer.
Stanford, CA (Scicasts) – Consider the marvel of the embryo. It begins as a glob of identical cells that change shape and function as they multiply to become the cells of our lungs, muscles, nerves and all the other specialized tissues of the body.
Raleigh, NC (Scicasts) – In a new study, researchers from North Carolina State University, UNC-Chapel Hill and other institutions have taken the first steps toward creating a roadmap that may help scientists narrow down the genetic cause of numerous diseases.
Chevy Chase, MD (Scicasts) – The complexity of biology can befuddle even the most sophisticated light microscopes. Biological samples bend light in unpredictable ways, returning difficult-to-interpret information to the microscope and distorting the resulting image.
La Jolla, CA (Scicasts) – Scientists at the Salk Institute have uncovered details into a surprising—and crucial—link between brain development and a gene whose mutation is tied to breast and ovarian cancer.
Memphis, TN (Scicasts) – The St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project found mutations in the tumour suppressor gene TP53 in 90 percent of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer.
Cambridge, MA (Scicasts) – Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation.
Hinxton, UK (Scicasts) – Researchers have found that people born with a rare abnormality of their chromosomes have a 2,700-fold increased risk of a rare childhood leukaemia. In this abnormality, two specific chromosomes are fused together but become prone to catastrophic shattering.
Cambridge, MA (Scicasts) – You’re on a crowded subway car and someone nearby sneezes. Influenza viruses shed by your fellow rider are expelled in droplets of saliva that land on you and the person next to you. Two days later, you begin suffering from the classic flu symptoms of fever, aches, and runny nose, while the lucky rider next to you somehow dodges the infectious bullet.
Bloomington, IN (Scicasts) – Scientists at Indiana University have unlocked one of the mysteries of modern genetics: how acquired traits can be passed between generations in a process called epigenetic inheritance.
Hinxton, UK (Scicasts) – Researchers have identified two novel cancer genes that are associated with the development of a rare, highly aggressive, cancer of blood vessels. These genes may now act as markers for future treatments and explain why narrowly targeted therapies that are directed at just one target fail.
St. Louis, MO (Scicasts) – Our genome, we are taught, operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein-synthesizing machinery in the cytoplasm. These instructions are conveyed by a type of molecule called messenger RNA (mRNA). [Videos]
Ann Arbor, MI (Scicasts) – Scientists have discovered a previously unrecognized gene variation that makes humans have healthier blood lipid levels and reduced risk of heart attacks -- a finding that opens the door to using this knowledge in testing or treatment of high cholesterol and other lipid disorders.
Cold Spring Harbor, NY (Scicasts) – Reproductive cells, such as an egg and sperm, join to form stem cells that can mature into any tissue type. But how do reproductive cells arise? We humans are born with all of the reproductive cells that we will ever produce. But in plants things are very different.
Seattle, WA (Scicasts) — Imagine yourself examining species of coral in Fiji. Looking at fungi and parasites in grass seeds. Following ants across the ground up close, or picking out the striations in a piece of roast beef on rye.
Tempe, AZ (Scicasts) – Some three billion base pairs make up the human genome – the floorplan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights relevant to human health and disease.
Hinxton, UK (Scicasts) – Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development.
Providence, RI (Scicasts) – The difference between merely throwing around buzzwords like "personalized medicine" and "big data" and delivering on their medical promise is in the details of developing methods for analyzing and interpreting genomic data.
Hinxton, UK (Scicasts) – Researchers have explored the role of a master gene that controls the functioning of other genes involved in heart development. Variations in this gene - NR2F2 - are responsible for the development of severe forms of congenital heart disease.
Hinxton, UK (Scicasts) – Researchers have discovered that mutations in a specific gene are responsible for a hereditary form of melanoma.
Boston, MA (Scicasts) – A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body.
Berkeley, CA (Scicasts) – An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers - sequences of DNA that act to amplify the expression of a specific gene – in the genomes of humans and other mammals.
La Jolla, CA (Scicasts) – A joint study by researchers at the University of California San Diego and the University of Toronto has found that a computer system spots real or faked expressions of pain more accurately than people can.
Kansas City, KS (Scicasts) – Proteins, like people, can be complex and mysterious – at least to the scientists studying them. Some two decades after discovering adenomatous polyposis coli (APC), researchers are still puzzling out this particular protein’s secrets.
Bloomington, IN (Scicasts) – Scientists from Indiana University are part of a consortium that has described the transcriptome of the fruit fly Drosophila melanogaster in unprecedented detail, identifying thousands of new genes, transcripts and proteins.
Cambridge, MA (Scicasts) – It's a jungle in there. In the tightly woven ecosystem of the human gut, trillions of bacteria compete with each other on a daily basis while they sense and react to signals from the immune system, ingested food, and other bacteria.
Houston, TX (Scicasts) – Open, feed, cut. Such is the humdrum life of a motor molecule, the subject of new research at Rice University, that eats and excretes damaged proteins and turns them into harmless peptides for disposal.
Blackburg, VA (Scicasts) – Researchers at Virginia Tech and the Massachusetts Institute of Technology have used a computer-aided design tool to create genetic languages to guide the design of biological systems.