Philadelphia, PA (Scicasts) – In 2010, scientists in Italy reported that a woman and her daughter showed a puzzling array of disabilities, including epilepsy and cleft palate.
La Jolla, CA, and Nashville, TN (Scicasts) – Researchers at The Scripps Research Institute (TSRI) and Vanderbilt University have created the most detailed 3-D picture yet of a membrane protein that is linked to learning, memory, anxiety, pain and brain disorders such as schizophrenia, Parkinson’s, Alzheimer’s and autism.
Providence RI (Scicasts) – When a person becomes sick or is exposed to an unwelcome substance, the body mobilizes specific proportions of different immune cells in the blood. Methods of discovering and detecting those profiles are therefore useful both clinically and in research.
Princeton, NJ (Scicasts) – An essential weapon in the body's fight against infection has come into sharper view. Researchers at Princeton University have discovered the 3D structure of an enzyme that cuts to ribbons the genetic material of viruses and helps defend against bacteria.
New York, NY (Scicasts) – In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults.
Santa Barbara, CA (Scicasts) – New research by UC Santa Barbara's Kenneth S. Kosik, Harriman Professor of Neuroscience, reveals some very unique evolutionary innovations in the primate brain.
Gaithersburg, MD (Scicasts) – In December 2013, the U.S. Food and Drug Administration approved the first high-throughput DNA sequencer (also known commonly as a "gene sequencer"), an instrument that allows laboratories to quickly and efficiently sequence a person's DNA for genetic testing, medical diagnoses and perhaps one day, customized drug therapies.
Rolla, MO (Scicasts) – Plant roots and certain human membrane systems resist chemical transport in much the same way, say researchers at Missouri University of Science and Technology in a recent journal article.
Memphis, TN (Scicasts) – The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumour ependymoma and evidence that the alteration drives tumour development.
Richland, WA (Scicasts) – In biology, a protein's shape is key to understanding how it causes disease or toxicity. Researchers who use X-rays to takes snapshots of proteins need a billion copies of the same protein stacked and packed into a neat crystal.
Vienna, Austria (Scicasts) – Usually averaging is a good thing that can make life a lot easier. For example, when you eat out with a group of friends and it comes to paying. If everyone had a meal and a drink and you split the bill total by the number of people, everyone will pay pretty close to what they would have paid for their individual meal and drink.
Hinxton, UK (Scicasts) – Researchers at the Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute have developed software that predicts the likelihood of variants in non-coding regions - relatively unknown regions of DNA that make up 98 per cent of genome - having a functional role.
Philadelphia, PA (Scicasts) – All creatures great and small, including fruitflies, need sleep. Researchers have surmised that sleep – in any species -- is necessary for repairing proteins, consolidating memories, and removing wastes from cells. But, really, sleep is still a great mystery.
Kansas City, MO (Scicasts) – Disruptive clumps of mutated protein are often blamed for clogging cells and interfering with brain function in patients with the neurodegenerative diseases known as spinocerebellar ataxias.
Blacksburg, VA (Scicasts) – For a cancer cell, it pays to have a group of eccentric friends.
Berkeley, CA (Scicasts) – A central question has been answered regarding a protein that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering.
Copenhagen, Denmark (Scicasts) – Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes.
Hinxton, UK (Scicasts) – Researchers from the Wellcome Trust Sanger Institute and the Model Animal Research Center of Nanjing University, China, have developed a safer way of genome editing. This method can be used on any organism and dramatically minimizes the problem caused by unplanned damage to other regions of the genome.
Washington, DC (Scicasts) – Astronauts floating weightlessly in the International Space Station may appear carefree, but years of research have shown that microgravity causes changes to the human body. Spaceflight also means exposure to more radiation. Together, microgravity and radiation exposure add up to pose serious health risks.
New York (Scicasts) – A new study led by Weill Cornell Medical College scientists shows that the most common genetic form of mental retardation and autism occurs because of a mechanism that shuts off the gene associated with the disease.
Barcelona, Spain (Scicasts) – A study led by Dr. Roderic Guigó from the Centre for Genomic Regulation in Barcelona, as part of the Chronic Lymphatic Leukaemia Genome Consortium, has made new advances in the study of this disease.
Coral Gables, FL (Scicasts) – There are more than a trillion cells called neurons that form a labyrinth of connections in our brains. Each of these neurons contains millions of proteins that perform different functions. Exactly how individual proteins interact to form the complex networks of the brain still remains as a mystery that is just beginning to unravel.
Cambridge, MA (Scicasts) – Researchers from the Broad Institute and MIT have teamed up with colleagues from the University of Tokyo to form the first high definition picture of the Cas9 complex – a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells.
Vienna, Austria (Scicasts) – How do new genes arise? Current research shows that so-called "orphan genes" may appear as if by magic as a result of mutations in segments of DNA that previously had no function.
New York, NY (Scicasts) – In the hunt for genetic mutations that cause cancer, there is a lot of white noise. So although genetic sequencing has identified hundreds of genetic alterations linked to tumours, it’s still an enormous challenge to figure out which ones are actually responsible for the growth and metastasis of cancer.
San Francisco, CA (Scicasts) – Sometimes biology is cruel. Sometimes simply a one-letter change in the human genetic code is the difference between health and a deadly disease.
Providence, RI (Scicasts) – For years, researchers have been investigating how mutations of a gene called Indy (for "I'm Not Dead Yet") affect metabolism, life span, and reproductive fitness in both mammals and fruit flies.
Boston, MA (Scicasts) – A new microscopy method could enable scientists to generate snapshots of dozens of different biomolecules at once in a single human cell, a team from the Wyss Institute of Biologically Inspired Engineering at Harvard University reported Sunday in Nature Methods.
Hinxton, UK (Scicasts) – Scientists have sequenced the genome of the world's oldest continuously surviving cancer, a transmissible genital cancer that affects dogs. [Video]
Lund, Sweden (Scicasts) – Researchers at Lund University have managed to develop a technique whereby they can study the inflammatory process that takes place in the pancreas during the natural development of type 1 diabetes, allowing for real time and repeated non-invasive imaging of individual islets of Langerhans.