Gene Tech

New Cost-Effective Genome Assembly Process

Walnut Creek, CA (Scicasts) – The U.S. Department of Energy Joint Genome Institute (DOE JGI) is among the world leaders in sequencing the genomes of microbes, focusing on their potential applications in the fields of bioenergy and environment.

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The glowing areas in this zebrafish embryo show the activity of one of the brain enhancer sequences identified. The enhancer is directing the activity of a gene in the lower areas of the central nervous system and in the lens of the eye. Image: G. Burzynski

Scientists Teach Computers to ID Regulating Gene Sequences

Baltimore, MD (Scicasts) – Johns Hopkins researchers have succeeded in teaching computers how to identify commonalities in DNA sequences known to regulate gene activity, and to then use those commonalities to predict other regulatory regions throughout the genome.

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Dr Muy-Teck Teh. Photo: Queen Mary, University of London

New Gene Test That Can Detect Early Mouth Cancer Risk Developed

London, UK (Scicasts) – Researchers from Queen Mary, University of London have developed a new gene test that can detect pre-cancerous cells in patients with benign-looking mouth lesions. The test could potentially allow at-risk patients to receive earlier treatment, significantly improving their chance of survival.

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Because gold nanoparticles have a slight positive charge from the ligands, and DNA is always negatively charged, the DNA and nanoparticles are pulled together into complex packages. Image by: Yaroslava Yingling, North Carolina State University.

Gold Nanoparticles 'Unzip' DNA

Raleigh, North Carolina (Scicasts) – New research from North Carolina State University finds that gold nanoparticles with a slight positive charge work collectively to unravel DNA’s double helix. [Video]

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Researchers Use  Powerful Sequencing Technology to Decodes DNA Folding Pattern

Researchers Use Powerful Sequencing Technology to Decodes DNA Folding Pattern

New York, NY (Scicasts) – Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus.

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Frequently described as bow-tie-shaped, a yeast chromosome has two arms that are positioned similarly to the two sides of a bow-tie. Image by: Jef D. Boeke and Sarah Richardson, Johns Hopkins University.

Chromosome 'Arm' Synthesized in Laboratory

Arlington, VA (Scicasts) -  Scientists have synthesized from scratch a so-called chromosome 'arm' -- 1 of the largest DNA molecules ever synthesized, and developed a new method for shuffling an organism's genetic deck, according to a report by the National Science Foundation.

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Thirty-five percent of Americans have dieted an average of six times in their life with little to no success; GenoVive offers a new approach using DNA to optimize weight loss.

New Genetic Solution to Weight Management Launched by GenoVive

New Orleans, LA (Scicasts) - GenoVive has announced the launch of a personalized approach to weight loss and sustained healthy eating. This new program, created by the GenoVive scientists and chefs, tailors home-delivered meal programs and exercise plans to each unique metabolism and empowers consumers to achieve their weight loss goals. GenoVive provides a long-term lifestyle solution to healthy weight management and a better quality of life.

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The j5 software provides a single design for the SLIC, Gibson, CPEC and Golden Gate DNA assembly strategies and determines which would be most advantageous for a given construction project.

Faster, More Efficient DNA Technology Developed

Berkeley, CA (Scicasts) - DNA construction, also known as DNA cloning or recombinant DNA technology - among a host of other terms - is one of the principal tools of modern biotechnology, used for a wide variety of purposes, including genetic studies, medical research, and the development of advanced biofuels.

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First Comprehensive Gene Map of the Human Brain Announced

First Comprehensive Gene Map of the Human Brain Announced

Seattle, WA (Scicasts) - The Allen Institute for Brain Science has released the world's first anatomically and genomically comprehensive human brain map, a previously unthinkable feat made possible through leading-edge technology and more than four years of rigourous studies and documentation. The unprecedented mappings are the foundation for the Allen Human Brain Atlas, an online public resource developed to advance the Institute's goal to accelerate understanding of how the human brain works and fuel new discovery among the global research community.

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Why Stem Cells Don't Just Want to Make Neurons

Why Stem Cells Don't Just Want to Make Neurons

London, UK (Scicasts) - Research being presented today (01 April) at the UK National Stem Cell Network annual science conference provides another piece in the puzzle of why it can be so hard to produce large numbers of the same type of cell in the lab – a process that is vital for scaling up stem cell production for therapeutic use. This knowledge will help researchers to develop strategies for obtaining the desired cell type for use in either research or medicine.

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Personalized Therapy to Treat Range of Cancers Created

Personalized Therapy to Treat Range of Cancers Created

Detroit, MI (Scicasts) - A Wayne State University School of Medicine physician-researcher has developed a personalized therapy to treat a wide range of cancers. According to the report from the university, the treatment is based on a naturally occurring human enzyme that has been genetically modified to fool cancer cells into killing themselves.

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Scientists Unravel Blood Stem Cells Regeneration Process

Scientists Unravel Blood Stem Cells Regeneration Process

Victoria, Australia (Scicasts) – According to a report from the Walter and Eliza Hall Institute, scientists  have begun to unravel how blood stem cells regenerate themselves, identifying a key gene required for the process.

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Modified mRNAs Open Up New Therapeutic Possibilities

Modified mRNAs Open Up New Therapeutic Possibilities

Munich, Germany (Scicasts) - Defects in the genome are the cause of many diseases. Gene therapy – direct replacement of mutant genes by intact DNA copies – offers a means of correcting such defects.

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Using Mother's Stem Cells to Treat Genetic Disease Before Birth

Using Mother's Stem Cells to Treat Genetic Disease Before Birth

San Francisco, CA (Scicasts) - Researchers at The University of California, San Francisco (UCSF)  have tackled a decade-long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth. Through a series of mouse model experiments, the research team determined that a mother's immune response prevents a foetus from accepting transplanted blood stem cells, and yet this response can be overcome simply by transplanting cells harvested from the mother herself.

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This rooster has been genetically-modified to prevent the spread of bird flu if he is infected with the disease. This genetic modification has the potential to stop bird flu outbreaks spreading within poultry flocks. This image relates to an article that appeared in the Jan. 14, 2011, issue of Science, published by AAAS. The study, by Dr. Lyall at University of Cambridge in Cambridge, UK, and colleagues was titled, 'Suppression of Avian Influenza Transmission in Genetically Modified Chickens.' Image by Norrie Russell, courtesy of Valerie White and The Roslin Institute.

Genetically Modified Chickens in the Fight Against Bird Flu

Edinburgh, Scotland and London, UK (Scicasts) – According to research performed by scientists at the Roslin Institute and Cambridge University, a Bird flu epidemics could be prevented by a new strain of chickens that do not spread avian flu to other birds.

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Criminal Virus Spreaders Revealed Using Evolutionary Forensics

Criminal Virus Spreaders Revealed Using Evolutionary Forensics

Austin, TX (Scicasts) - The source of HIV infection in two separate criminal cases in which men were convicted of intentionally infecting their female sexual partners was confirmed by scientists from The University of Texas at Austin and Baylor College of Medicine using evolutionary forensics.

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